What Causes Some People to Feel Depressed When They Ingest MDMA?

Many people are wondering: What Causes Some People to Feel Depressed When They Ingest MDMA? The answer varies among individuals, but MDMA is known to cause serotonin syndrome, a condition that occurs when the brain produces too much serotonin. This is especially common in individuals who are vulnerable to depression. Although there are no definitive answers to this question, researchers have found that the drug’s side effects are minimal.

Serotonin Depletion

The serotonin receptors are responsible for regulating our mood. When we take MDMA, we activate them and experience feelings of happiness, empathy, sociability, and heightened senses of touch. As the drug enters our bloodstream, the receptors begin to degrade. We then feel low or irritable. Eventually, these chemicals leave our bodies and we feel down.

However, MDMA has other effects on the serotonin system that may make some people more susceptible to depression. Ingesting the drug in moderate to high doses can damage serotonin-containing nerve cells. In addition to destroying these cells, MDMA also affects the tryptophan hydroxylase enzyme, which is necessary for the recycling of serotonin. These additional effects are why some people feel depressed after consuming MDMA.

Studies have shown that frequent use of MDMA can lead to depression, but this effect is not permanent. In addition to the chemical itself, MDMA can cause your body to become less responsive to serotonin and increase the risk of developing a mental illness. As a result, some people who consume it frequently experience severe depression. To treat this problem, you should start eating healthy, which means eating more foods with complete proteins, vitamins, and minerals.

Serotonin is the neurotransmitter in the brain that causes people to experience high-speed emotions. However, it can also be linked to depression, if not to the substance itself. Some of the studies on this subject have shown that MDMA can cause depression in some people. While most people do not experience depressed feelings when taking MDMA, it may be beneficial in treating some forms of PTSD and depression.

While there are no specific reasons to avoid MDMA, it is important to understand that the drug can make people become depressed. This is true regardless of whether the drug causes the depressed feelings, but it should be kept in mind. Most of the effects of MDMA are mild and only last a few days. In the long run, regular use of MDMA can lead to severe depression.

A Study Found That MDMA May Improve Depression

There have been some studies on ecstasy. Creighton, M., and Black, D.L., studied this substance. In contrast, a few studies have suggested that consuming ecstasy has not been linked to increased depressive symptoms. These findings are inconsistent, and the research on ecstasy isn’t clear.

The study found a correlation between MDMA use and the BDI score. While this is not a definitive proof that MDMA causes depression, it is worth mentioning that people who use the drug may be using the drug as a way to relieve their depression symptoms. The fact that the drug increases serotonin levels in the brain makes it possible for it to help people with depression, but this research is still lacking sufficient data to make a final conclusion.

Take MDMA in Moderation

It’s possible that the drug’s side effects are due to long-term dependence. The effects of MDMA depend on how long the drug was taken. The longer the person uses MDMA, the more likely they will develop depression. It may even lead to severe mental health issues, so many people who are addicted to MDMA are at risk of becoming depressed. They are asymptomatic while others are depressed for days or weeks.

Another study has found that MDMA causes the brain’s receptors to turn off. This is a possible cause of depression. In fact, the drug is responsible for a mild depression, but it may also cause people to feel anxious. When someone drinks too much of the drug, the receptors may turn on again, leading to a depressed mood. This is a common side effect of the drug, so it is important to understand the reason why it affects your mood. Always stay safe and make sure to test your molly to ensure its purity.

Categorized as MDMA

Alexander Shulgin and the story of MDMA

It extends here, he explained, while he built the molecule with hand gestures.
For a chemist, it was probably obvious what was happening there in the thin air in front of him. For me it was completely incomprehensible, yet incredibly fascinating. There is something very beautiful and attractive about people who are so involved in what they do.

The Story of His Life’s Work

The rest of the audience seemed to know exactly who he was, but I stumbled into the lecture without a clue. Alexander Shulgin, and next to him his wife Ann Shulgin. Both gray-haired, old, but with a sparkling natural glow that lit up the room. Together they spun the story of his life’s work.

Alexander made it his life’s work to synthesize and develop new psychedelics. He then tested them with his wife, before they tested them together with friends.

  1. How do you usually do when you try them the first time? asked one of the audience.
  2. Well, usually we’re in the bedroom. Many of these substances have lovely erotic effects, said Ann Shulgin and made the audience giggle in recognition.

His two books PIHKAL and TIHKAL (Phenethylamines and Tryptamines I Have Known And Loved) include all the basic information on the magical molecules which he discovered. He published all the recipes, so that the pharmaceutical industry could not patent them, and thus keep them away from the public. Best known of all the substances attributed to Shulgin is not a discovery, but the rediscovery of MDMA – the sought-after ingredient in Ecstasy.

What Does MDMA Feel Like?

MDMA releases serotonin in the brain, leading to extremely happy and emphatic states. In this lies both the substance’s blessing as its curse. If you are over using MDMA, it is easy to burn out the reserves and plummet into depression and feelings of emptiness and meaninglessness. However, if you use it with proper caution and with an intention, then it can be a miraculous remedy for such things as depression, anxiety of death, post-traumatic stress, substance abuse, empathy disorders and the like.

MDMA First Used by Therapists

That was the main area where the substance was first made available – it was used with excellent results by therapists to help people who were stuck in different ways. However, the substance was soon picked up in club and rave culture, and when the establishment saw how strangely the youths started dancing and behaving it was banned.
What do you think happened next?

Well, criminal organizations took over the manufacturing and distribution of the substance. MDMA became big business for the Mafia, militant groups, motorcycle gangs and suburban gangs. Quality control disappeared and consumers could not be sure that the substance was pure or what strength it held. That is why you should always test your molly so that you avoid adverse reactions and stay safe!

Young people continued to experiment in such a high degree that it can rightly be considered the single most important ingredient for the development of rave culture. The availability is high and many people use it, but because it is illegal, many safety nets fail. For example, if someone would feel acutely bad, many would avoid contacting authorities because they would risk getting caught.

Of course some people are getting caught, but it is rarely at the level in the criminal organizations where it actually matters. Many people who get caught are very young and are at the bottom of the chain, sometimes only as users. They are judged and stigmatized accordingly and lose opportunities in life, with no effect on supply or demand.

Clinical Studies Begining to Emerge

The big losers, however, are all those suffering from death anxiety, depression, substance abuse, post-traumatic stress and empathy disorders. They are war-traumatized, rape victims, cancer patients, drug users, those who have lost children, those who no longer dare to feel emotions and those who see life in gray. They are the ones that are deprived of a legitimate and powerful therapeutic tool.

Only now, 30 years after MDMA was banned, clinical studies are beginning to be permitted on a very small scale. Not surprisingly they show stunning results and cures.

Categorized as MDMA

The History and Benefits of MDMA

The History 

The history of ecstasy is quite interesting. This drug was developed in Germany in the 1900 in order to produce other medications. It was first used as a psychotherapeutic tool before it underwent clinical trials. In the late 2000 MDMA ecstasy underwent the first clinical trial to see if the drug could be used on psychotherapy to treat post-traumatic stress disorder. 

In the 1970s and 1980s the drug was known to enhance communication in patients who were having trouble expressing their feelings. After this MDMA ecstasy became widely available on the street. Later on it was banned by the Drug Enforcement Administration (DEA).

MDMA Became Popular Among College Students

MDMA ecstasy became very popular among college students during the 1999s. This drug increases energy, alertness, and creates feelings of euphoria. 

Users may also have:

  • An increased sensitivity of light
  • Improved sense of touch 
  • And sensuality which can easily lead to sexual stimulation

Ecstasy can lead to physical damages and become very addictive. Because this drug is very similar to methamphetamine it can lead to arrhythmia, constrict the vascular system causing overheating. When MDMA is adulterated with harmful drugs, the results can be deadly. That is why it crucial that you test your molly with a Marquis Reagent testing kit. 

When the body temperature is this high, a person’s organs can be damaged, specially the kidney, liver, and cardiovascular system which may result in death. 

MDMA users can also experience loss of appetite, lack of concentration, tiredness, and depression. Individuals who abuse this drug are often experimenting with other drugs which may increase the dangers of physical and psychological damage.


PTSD has so far shown imporvements with the use of MDMA. More medicinal use of MDMA is underway. Learn more about MDMA and and its benefits. 

Categorized as MDMA